We use cookies to ensure you get the best experience on our website. Use of this site signifies your agreement to the use of cookies.

BIOHIT ColonView® Hb+Hb/Hp FOB test

Digestive tract canceris gaining a leading position as regards the worldwide occurrence of carcinomas in comparison to other organ systems. Currently, colorectal cancer has the leading position among digestive tracts carcinoma.

The majority of carcinomas arise from polyps - small outgrowths on intestinal mucosa. The polyp shows the first sign of disease when it bleeds continuously or intermittently and blood is released into stool. This bleeding may not be seen in the stool with the naked eye, however, it is possible to detect the free haemoglobin released from a disintegrated erythrocyte and haemoglobin bound to haptoglobin – the so-called haemoglobin/haptoglobin complex.

If a polyp is detected in an early stage, it is possible to remove it endoscopically. If it is ignored, it can develop into a malignant tumour forming a carcinoma.

The screening (active searching) of colorectal carcinoma reduces mortality from CRC by increasing the number of patients diagnosed at an early stage. Therefore, it is vital to attend routine check-ups that also include a test to detect faecal occult bleeding (FOB). Routine check-ups with CRC screening are performed every two years for patients over 50 (Všeobecná zdravotná poisťovňa covers the costs from the age of 40) or without any age limit for patients who have a family history of this disease.

Current FOB tests can identify the presence of haemoglobin in stool. The older tests that use guaiac resin provide a lower sensitivity and specificity as they also detect animal blood as well as human blood and can interact with some other types of food (meat, some types of vegetables). The more recent immunochemical tests show a higher specificity and sensitivity; it is not necessary to follow a specific diet before their application and thus false positives are minimized.

Haemoglobin is unstable in the environment outside an erythrocyte and degrades relatively rapidly during its transfer through the large intestine. Thus, the classic FOB tests based on the detection of haemoglobin may not detect bleeding from polyps, adenomas or carcinomas localized in a proximal part of colon and thus might give a false negative.

BIOHIT ColonView®Hb+Hb/Hp Quick Test

  • We are the first in Slovakia, to detect two parameters based on a single stool sample – haemoglobin and haemoglobin and haptoglobin complex (Hb+Hb/Hp).
  • The Hb/Hp complex is more stable in comparison to haemoglobin and thus also allows the detection of bleeding in the proximal parts of the large intestine and the upper parts of the digestive tract.

Test principle: Antibodies for human haemoglobin and haptoglobin are put onto the membrane of a test cassette in the test region area (T). Antibodies for mouse haemoglobin are in the control region area (C). The result of the test is assessed according to the intensity of discoloration of the lines formed based on the concentration of a conjugate of colloidal gold and the antibodies in the T and C cassette regions.

The result is assessed exactly 15 minutes later.

The test is evaluated as “positive” if both lines are coloured in both the control (C) and test (T) regionin at least one of the two tests (Hb or Hb/Hp).

The test has a low limit for the detection of haemoglobin (15 ng/ml) and Hb/Hp complex (4 ng/ml). (1)

The sensitivity of the tests amounts to 97.3% and sensitivity for the proximal colon is 100%. (2)

The test itself is simple; a modern sample collection tube is part of a kit.

The examination of three stool samples for a period of no longer than 3 days in a row increases the probability of detection of intermittent bleeding.

The closed sampling system ensures hygienic manipulation.

The sample will be stable for 5 days at room temperature and for 11 days in a refrigerator.

ColonView3.jpg
ColonViewnavodPopis.jpg
Colonview_Rady_pre_pacientov_web.jpg

About us

We are a Slovak company representing selected foreign producers offering innovative solutions in the area of diagnostics and treatment of gastrointestinal diseases.

Therapeutic areas

Billing data

Aloris Vital, s.r.o.
Majoránová 62
821 07 Bratislava-Vrakuňa
Slovakia

ID: 47 419 105
TAX ID: 2023861488
VAT ID: SK2023861488

info@alorisvital.sk